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|Motif Bio to Present Three Posters at IDWeek 2017|
The title and description of each poster and presentation times are noted below. All posters will be exhibited at the
(1) A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positive Pathogens (REVIVE-1). This is a 600 patient study comparing iclaprim 80 mg to vancomycin 15 mg/kg both administered intravenously every 12 hours for 5 to 14 days at the endpoints: early clinical response (20% or more reduction in lesion size) and test of cure (resolution of signs and symptoms of ABSSSI such that no further antibiotics are needed).
These data will be presented at the Clinical Study with New Antibiotics and Antifungals session on
(2) Effects of Iclaprim and Trimethoprim on Exotoxin Production by Methicillin-resistant Staphylococcus aureus. This is an in vitro study comparing the effects of sub-inhibitory doses of dihydrofolate reductase inhibitors with cell wall-active agents on transcription and translation of important and common toxins (alpha hemolysin, Panton-Valentine Leukocidin and toxic shock syndrome toxin-1) from two clinical MRSA isolates.
These data will be presented at the Expanded Spectrum – New Antimicrobial Susceptibility Testing session on
(3) Efficacy Evaluation of Iclaprim in a Neutropenic Rat Lung Infection Model with Methicillin-Resistant Staphylococcus aureus Entrapped in Alginate Microspheres. This is an in vivo study comparing the colony forming unit (CFU) reduction and mortality of rats in an experimental animal model of a chronic pulmonary infection using a strain of methicillin resistant S. aureus and treatment with iclaprim compared to vancomycin. Bacterial reduction and mortality were measured in this experimental animal model of a chronic pulmonary infection which mimics the pathophysiology observed in patients with cystic fibrosis.
These data will be presented at the Preclinical Study with New Antibiotics and Antifungals session on
Iclaprim is a novel antibiotic candidate, designed to be effective against bacteria that have developed resistance to other antibiotics. Iclaprim exhibits potent activity against Gram-positive clinical isolates of many genera of staphylococci, including methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). The MIC90 of iclaprim was lower, demonstrating higher potency, than most comparators including vancomycin and linezolid, standard of care therapies used in serious and life-threatening Gram-positive hospital infections. To date, iclaprim has been studied in over 1,000 patients and healthy volunteers. No dosage adjustment is required in patients with renal impairment, or in obese patients. The iclaprim fixed dose may help reduce the resources required in hospitals since dosage adjustment by health care professionals is avoided, and overall hospital treatment costs may be lower, especially in renally impaired patients.
IDWeek is attended by over 6000 healthcare professionals practicing or involved in infectious diseases and healthcare epidemiology and prevention, including researchers, clinicians, quality and patient safety practitioners, epidemiologists. In addition, public health officials, including those who see HIV and pediatric patients attend in numbers. It is a meeting for professionals who want to stay current and apply state-of-the art science to clinical care, and excel in their own career.
This press release contains forward-looking statements. Words such as “expect,” “believe,” “intend,” “plan,” “continue,” “may,” “will,” “anticipate,” and similar expressions are intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other important factors that may cause Motif Bio’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.
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