When was Motif Bio founded and where is it incorporated?
Motif Bio plc was incorporated in England and Wales on November 20, 2014. Motif Bio’s subsidiary, Motif BioSciences Inc. was incorporated in Delaware on December 2, 2003.

Where are Motif Bio’s corporate headquarters?
The registered office of Motif Bio is at 27/28 Eastcastle Street, London, W1W 8DH.

The company conducts its day to day operations from 125 Park Avenue, 25th Floor, Suite 2510, New York, NY 10011.

When is the company’s financial year end?
Motif Bio's financial year end is December 31st.

How do I obtain a copy of the company’s annual report?
Motif Bio’s annual report, interim report and other press releases can be downloaded from Motif Bio’s website. To receive a hard copy of Motif Bio’s latest annual report, please contact us at ir@motifbio.com.

Where can I find recent Motif Bio press releases?
You can view Motif Bio’s recent press releases by visiting the “News Releases” section of the website. If you would like to receive press release email alerts, please visit the “Investors” section of the corporate website and choose the "Email Alerts" icon.

Which stock exchanges is Motif Bio listed on?
The ordinary shares of Motif Bio are listed on the AIM market of the London Stock Exchange. Motif Bio also has American Depositary Shares (each of which represents 20 ordinary shares) (“ADSs”) and warrants to purchase ADSs listed on the Nasdaq Capital Market. The stock is listed on both exchanges under the symbol ‘MTFB’. The warrants are listed on the Nasdaq Capital Market under the symbol ‘MTFBW’.

What form did the U.S. Listing take?
The U.S. listing was of ADSs and warrants to purchase ADSs to shareholders who invested in Motif Bio’s U.S. public offering.

Where can I view documents that Motif Bio has filed with AIM and the U.S. Securities & Exchange Commission (SEC)?
Motif Bio’s regulatory filings and announcements can be accessed under "Financial Information" in the "Investors" section of our corporate website or www.londonstockexchange.com or www.sec.gov.

Will demand from U.S. Shareholders have a positive effect on the AIM Ordinary Share price?
The price for both ADSs and ordinary shares should be related, and should fluctuate in tandem according to the level of supply and demand in the two markets.

What is an ADS?
An ADS is a U.S. dollar-denominated equity share of a non-U.S. company available for purchase on an American stock exchange. ADSs are issued by depository banks in the U.S. under agreement with the issuing company.

HOW DO I CONVERT AIM SHARES INTO ADSs
You may convert some or all of your ordinary shares into ADSs. To do so, download the instructions and forms (Click Here to Download Zip Folder) and complete the applicable procedures.

What types of companies issue ADSs?
Non-U.S. companies seeking to raise capital in the U.S. or increase their base of U.S. investors may seek to issue ADSs.

What is an ADS/Ordinary Share ratio?
This ratio reflects the number of ordinary shares that correspond to 1 ADS. In the case of Motif Bio, each ADS represents 20 ordinary shares.

How can I buy an ADS?
You can buy an ADS through a broker, just as you would any other U.S. securities.

Can UK shareholders invest in Motif Bio’s ADSs?
Yes, it is possible for UK shareholders to purchase ADSs directly or to convert their UK ordinary shares into ADSs. We would advise that UK shareholders seek advice from their broker and/or tax adviser.

Are holders of ADSs entitled to vote at Motif Bio’s annual general meeting?
Holders of ADSs may authorise The Bank of New York Mellon, Motif Bio’s Depositary, to act as a proxy in exercising voting rights according to the number of ordinary shares represented by their respective ADSs.

When I want to buy Motif Bio’s securities, how does it work in practice?
When you instruct your broker to buy ordinary shares on your behalf, your broker will have the option of buying AIM listed ordinary shares, or buying NASDAQ listed ADSs and asking The Bank of New York Mellon, as depositary to convert them into ordinary shares. Conversely, when you wish to sell your position, your broker will either sell the ordinary shares you hold on AIM, or otherwise, may sell them to the Bank of New York Mellon who will then sell them as ADSs on the NASDAQ market. In any event, this would be a seamless process for shareholders. Shareholders will not need to be concerned with which market their shares are purchased from or sold into; brokers will simply sell in the market where there is the most liquidity. If ordinary shares are held in certificated form, shareholders will be required to deliver a share certificate that will be deposited with The Bank of New York Mellon prior to executing a sale on NASDAQ.

What does a depository bank do?
A depositary is a bank that facilitates cross-border trading of an issuer’s shares. Among other things, depositary banks provide ADS issuance and cancellation services, and associated stock transfer services such as maintaining the register of holders, distributing dividends in U.S. dollars, providing annual meeting services and executing corporate actions. So, in practice, the depositary bank maintains records of the holders of ADSs and manages the flow of shares between the two separate markets, essentially converting Ordinary Shares into ADSs when there is demand in the U.S., and converting ADSs back into Ordinary Shares when there is demand for the Ordinary Shares. This service creates a liquidity between the two markets that will help minimize any price differential between the two markets.

How do I contact Motif Bio’s Depository Bank?
Motif Bio’s depositary bank is The Bank of New York Mellon. The office at which the ADSs are administered is at 101 Barclay Street, New York, NY 10286.

The Bank of New York Mellon's principal executive office is located at 225 Liberty Street, New York, NY 10286.

To access your account you can log on to The Bank of New York Mellon website at www.mybnymdr.com. The Bank of New York Mellon can be contacted by email at shrrelations@cpushareownerservices.com or by telephone at 1-888-269-2377.

I have lost my share certificate. Who do I contact for a replacement?
If you hold ordinary shares in Motif Bio, please contact Motif Bio's registrars, Share Registrars Limited, at The Courtyard, 17 West Street, Farnham, Surrey, GU9 7DR or by telephone on +44 1252 821390.

If you hold ADSs in Motif Bio please contact Motif Bio’s depositary, The Bank of New York Mellon. The office at which the ADSs are administered is located at 101 Barclay Street, New York, NY 10286 or by telephone on +1 412-234-5000.

Please note, there may be a fee involved for replacing lost certificates.

My contact address has changed. How do I report a change of mailing address?
For ordinary shares, you must send both your old and new addresses to Motif Bio’s registrar, Share Registrars Limited.

For ADSs, you must send both your old and new addresses to Computershare, Inc., whose address is 250 Royall Street, Canton, Massachusetts 02021.

Where shares are jointly held by more than one shareholder, each shareholder registered against the share in question must sign the request for an address change.

Who is Motif Bio’s corporate counsel?
Motif Bio’s corporate counsel is DLA Piper.

Who are Motif Bio’s financial advisers and brokers?
Peel Hunt is Motif Bio's nominated adviser and with Northland Capital Partners Limited is the joint broker for the purposes of the AIM Rules.

Who is Motif Bio’s registrar and transfer agent and how do I contact them?
For ordinary shares, Motif Bio's registrars are Share Registrars Limited who are based at The Courtyard, 17 West Street, Farnham, Surrey, GU9 7DR.

Who is Motif Bio’s independent registered public accounting firm?
Motif Bio’s independent registered public accounting firm is PricewaterhouseCoopers LLP.

How do I contact Investor Relations with a question or request?
For investor related questions, please send an email to ir@motifbio.com.

If I have questions regarding Motif Bio that have not been answered, whom should I contact?
Please email ir@motifbio.com.